• 1612: Antoine Lefèbvre
• 1849: Aristide Cavaillé-Coll
• 1976: Alfred Kern reconstruction

In 1609, a fire devastated the cathedral choir and destroyed an extraordinary set of five organs donated in 1463 by Archbishop Bertrand du Rozier. This ensemble, placed on the rood screen, consisted of a large organ placed in the centre, behind a positive. This large organ was itself surmounted by a third, smaller organ. On either side of this ensemble were the other two organs. The three instruments in the centre were reserved for the exclusive use of the cathedral chapter, the other two for the confraternities. On 8 August 1612, a contract was signed between Antoine Lefèbvre, master organist living in Tolosa, and the cathedral chapter for the reconstruction of the choir organ, for the sum of 9,000 livres. The following day, a second contract was concluded between Antoine Lefèbvre and J. Behorri, master carpenter, for the construction of the organ case, for the sum of 3,000 livres. The organ comprised 28 stops distributed over 2 manuals and pedal. It was later considerably enlarged, following the work of Jean de Joyeuse in 1677, Montbrun in 1738, Lépine in 1761, then Micot in 1772 and Rabiny in 1787. The organ then had to undergo various cleaning and transformation works and was finally ruined by the Claude brothers in 1838. Ten years later, Aristide Cavaillé-Coll submitted a proposal for a complete reconstruction, reusing much of the old material. The organ was accepted in 1852 by Alfred Lefébure-Wély. In 1868, work was carried out by Vincent Cavaillé-Coll; in 1878/79, the organ was restored by Eugène Puget, who made a number of transformations, including the application of timbre notches to 443 pipes. The instrument was restored again in 1947 by Maurice Puget. In 1970, the organ was in a very poor state of repair. On the initiative of Xavier Darasse, rapporteur of the Commission Supérieure des Monuments Historiques, and with the help of Claude Aubry, consultant technician, and Father Philippe Bachet, representing the titular organist Renée Darasse-Laroyenne, a reconstruction project was studied with the organ builder Alfred Kern from Strasbourg, using all the old pipes that had been preserved, as well as some of the 19th-century additions. Work began in 1973 and was completed in 1976. With its 47 stops on four manuals and pedalboard, the organ of the cathedral of Saint-Etienne in Toulouse has regained its original appearance, its ancient substance revitalised by the new contributions (Xavier Darasse). The Great Organ was classified as a Historic Monument, for its case, on 19 March 1971.